Paweł Kafarski

Education:

Dembowski High School # 13 in Zielona Góra;

M.S. 1971 , Wrocław University of Technology;

Ph.D. 1977, Wrocław University of Techhnology

Married (Dorota) and have two children (Błażej and Krzysztof).

Major teachers: Dr Zbigniew Czarnuch (high school) and Prof. Przemysław Mastalerz (university).

Hobby: hiking in Tatra Mountains; collecting post-stamps; collecting mushrooms.

e-mail: pawel.kafarski@pwr.wroc.pl

phone : +48 71 320 36 82

Research interests

The main stream of research considers design and synthesis of biologically active compounds within the group of compounds belonging to aminophosphonates 1 and phosphono peptides 2 and 3.

The studies are focused on inhibitors of specific enzymes in order to find out potential; magents against civilization diseses such as: cancer (aminopeptidases and cathepsins), tuberculosis (glutamine synthetase), malaria (aminopeptidases) or osteoporosis. Also search for new plant growth regulators and herbicides is carried out, which starts from screening of physiological activity of aminophosphopnates followed by determination of their molecular mechanisms of action or by design of specific plant enzyme inhibitors. In order to discover such compounds numerous efforts for their synthesis have been undertaken. They include elaboration of new synthetic schemes leading to aminophosphonates and phosphono peptides including stereospecific synthesis by means of conventional methods and biocatalysis. Also chemical properties of aminophosphonic acids and their derivatives have been studies, which include their configuration in solutions, formation of complexes with metal ions, spectroscopic studies, self-organization in solid phase and supramolecular properties. Also biodegradation of aminophosphonates, especially herbicide glyphosate, is studied in some details by NMR technique.

Professional memberships

Polish Chemical Society (President), American Chemical Society, European Peptide Society

Awards

Honorary Member of Slovak Chemical Society, Jan Hanus Medal (Czech Cemical Society), Włodzimierz Trzebiatowski Medal (Technological University of Wroclaw), numerous awards of Polish Minister of Science and Higher Education

Recent Publications

1. Berlicki, Ł.; Bochno, M.; Grabowiecka, A.; Białas, A.; Kosikowska, P.; Kafarski, P., N-Substituted aminomethanephosphonic and aminomethane-P-methylphosphinic acids as inhibitors of ureases. Amino Acids 2012, 42, 1937.
2. Forlani, G.; Petrolino, D.; Fusetti M.; Romanini, L.; Nocek, B.; Joachimiak, A.; Berlicki, L.; Kafarski, P., Delta1-Pyrroline-5-carboxylate reductase as a new target for therapeutics: inhibition of the enzyme from Streptococcus pyogenes and effects in vivo. Amino Acids 2012, accepted.
3. Jasicka-Misiak, I.; Paliwoda, A.; Dereń, M.; Kafarski, P., Phenolic compounds and abscisic acid as potential markers for the floral origin of two Polish unifloral honeys Food Chem. 2012, 131, 1149.
4. Górecki, Ł.; Berlicki, Ł.; Mucha, A.; Kafarski, P.; Ślepokura, K.; Rudzińska-Szostak, E., Phosphorylation as a Method of Tuning the Enantiodiscrimination Potency of Quinine – an NMR Study. Chirality 2012, 24, 318.
5. Forlani G.; Prearo V.; Wieczorek D.; Kafarski P.; Lipok J., Phosphonate degradation by Spirulina strains: Cyanobacterial biofilters for the removal of anticorrosive polyphosphonates from wastewater Enzyme Microb. Technol. 2011, 48, 199.
6. Radwan-Olszewska, K.; Palacios, F.; Kafarski, P., Selective Synthesis of α-Fluoro-β-keto- and α-Fluoro-β-aminophosphonates via Electrophilic Fluorination by Selectfluor J. Org. Chem 2011, 76, 1170.
7. Kowalik, T.; Pietruszka, M.; Jezierska, J.; Matczak-Jon, E; Kafarski, P., Copper(II) complexation by (pyridinyl)aminomethane-1,1-diphosphonic acid derivatives; spectroscopic and potentiometric studies Polyhedron 2011, 30, 1274.
8. Podstawka-Proniewicz, E.; Andrzejak, M.; Kafarski, P.; Kim, Y.; Proniewicz, L., Vibrational characterization of L-valine phosphonate dipeptides: FT-IR, FT-RS, and SERS spectroscopy studies andDFT calculations J. Raman Spectrosc. 2011, 42, 958.
9. Brzezińska-Rodak, M.; Klimek-Ochab, M.; Żymańczyk-Duda E.; Kafarski, P., Biocatalytic Resolution of Enantiomeric Mixtures of 1-Aminoethanephosphonic Acid Molecules 2011, 16, 5896.
10. Mucha, A.; Kafarski, P.; Berlicki, Ł., Remarkable potential of the alpha-aminophosphonate/phosphinate structural motif in medicinal chemistry. J. Med. Chem. 2011, 54, 5955.
11. Klimek-Ochab, M.; Brzezińska-Rodak, M.; Żymańczyk-Duda, E.; Lejczak, B.; Kafarski, P., Comparative study of fungal cell disruption—scope and limitations of the methods. Folia Microbiol. 2011, 56, 469.
12. Podstawka-Proniewicz, E.; Piergies, N.; Skołuba, D.; Kafarski, P.; Kim, Y.; Proniewicz, L. M., Vibrational Characterization of L-Leucine Phosphonate Analogues: FT-IR, FT-Raman, and SERS Spectroscopy Studies and DFT Calculations J. Phys. Chem. A 2011, 115, 11067.
13. Gluza, K.; Kafarski, P., Inhibitors of Proteinases as Potential Anti-Cancer Agents Book: Drug Development - A Case Study Based Insight into Modern Strategies 2011, 39.
14. Jasicka-Misiak, I.; Kafarski, P., Chemiczne markery miodów odmianowych Wiadomości Chemiczne 2011, 65, 821.
15. Kafarski, P., Chemia a biotechnologia przemysłowa Misja Nauk Chemicznych 2011, 1, 153.
16. Młynarz, P.; Lasek, B.; Kafarski, P.; Kozik, T.; Schroeder, G., Phosphono peptides and their host-guest chemistry. ESI MS study. Molecular Receptors. Collected Research Papers; Ed. V.I. Rybchenko 2011, 329.
17. Rudzińska, E.; Dziędzioła, G.; Berlicki, Ł.; Kafarski, P., Enantiodifferentiation of alpha–Hydroxyalkanephosphonic Acids in 31P NMR with Application of alpha–Cyclodextrin as Chiral Discriminating Agent. Chirality 2010, 22, 63.
18. Occhipinti, A.; Berlicki, Ł.; Giberti, S.; Dziędzioła, G.; Kafarski, P.; Forlani, G., Effectiveness and mode of action of phosphonate inhibitors of plant glutamine synthetase. Pest Manag. Sci. 2010, 66, 51.
19. Skinner-Adams, T. S.; Stack, C. M.; Trenholme, K. R.; Brown, C. L.; Grembecka, J.; Lowther, J.; Mucha, A.; Drag, M.; Kafarski, P.; McGowan, S.; Whisstock, J. C.; Gardiner, D. L.; Dalton, J. P., Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials. Trends Biochem. Sci. 2010, 35, 53.
20. McGowan, S.; Oellig, C. A.; Birru, W. A.; Caradoc-Davies, T. T.; Stack, C. M.; Lowther, J.; Skinner-Adams, T.; Mucha, A.; Kafarski, P.; Grembecka, J.; Trenholme, K. R.; Buckle, A. M.; Gardiner, D. L.; Dalton, J. P.; Whisstock, J. C. , Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases. Proc. Natl. Acad. Sci. U. S. A. 2010, 107, 2449.
21. Matczak-Jon, E.; Kowalik-Jankowska, T.; Ślepokura, K.; Kafarski, P.; Rajewska A., Specificity of the zinc(II), magnesium(II) and calcium(II) complexation by (pyridin-2-yl)aminomethane-1,1-diphosphonic acids and related 1,3-(thiazol-2-yl) and 1,3-(benzothiazol-2-yl) derivatives Dalton Trans. 2010, 39, 1207.
22. Prokopowicz, M.; Młynarz, P.; Kafarski, P., Zwiazki metalooorganiczne w syntezie fosfonianów Wiad. Chem. 2010, 64, 1.
23. Mucha, A.; Drąg, M.; Dalton, J. P.; Kafarski, P., Metallo-aminopeptidase inhibitors. Biochimie 2010, 92, 1509.
24. Doskocz, M.; Malinowska, B.; Młynarz, P.; Lejczak, B.; Kafarski P., Long range phosphorus–phosphorus coupling constants in bis(phosphorylhydroxymethyl)benzene derivatives Tetrahedron Lett. 2010, 51, 3406.
25. Vassiliou, S.; Kosikowska, P.; Grabowiecka, A.; Yiotakis, A.; Kafarski, P.; Berlicki, Ł., Computer-aided optimization of phosphinic inhibitors of bacterial ureases. J. Med. Chem. 2010, 53, 5597.
26. Majewska, P.; Kafarski, P.; Lejczak.B., Enzymatic resolution of ethyl α-hydroxyphosphinates in a modified reaction environment Phosphorus, Sulfur andSilicon 2010, 185, 1915.
27. Matczak-Jon, E.; Ślepokura, K.; Zierkiewicz, W..; Kafarski, P; Dąbrowska, E., The role of hydrogen bonding in conformational stabilization of 3,5,6- and 3,5-substituted (pyridin-2-yl)aminomethane-1,1-diphosphonic acids and related (pyrimidin-2-yl) derivative J. Mol. Structr. 2010, 980, 182.
28. E.Mytnik, J. Kuryszko, E. Chmielewska, P. Kafarski, Molekularny mechanizm działania bisfosfonianów i ich zastosowanie w praktyce klinicznej Medycyna Weterynaryjna 2010, 66, 307.
29. Lipok, J.; Wieczorek, D.; Jewgiński, M.; Kafarski, P., Prospects of in vivo 31P NMR method in glyphosate degradation studies in whole cell system Enzyme Microb. Technol. 2009, 44, 11.
30. Rydzewska, A.; Ślepkura, K.; Lis, T.; Kafarski, P.; Młynarz, P., Unexpected formation of hydroxyborazaphosphonic acid in the reaction of (N-benzyl)benzylideneimine-2-boronic acid with diethyl phosphite Tetrahedron Lett. 2009, 50, 132.
31. McGowan, S.; Porter, C. J.; Lowther. J.; Stack, C. M.; Golding, S. J.; Skinner-Adams, T. S.; Trenholme, K. R.; Teuscher, F.; Donnelly, S. M.; Grembecka, J.; Mucha, A.; Kafarski, P.; Degori, R.; Buckle, A. M.; Gardiner, D. L.; Whisstock, J. C.; Dalton, J. P., Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proc. Natl. Acad. Sci. U. S. A. 2009, 106, 2537.
32. Doskocz, M.; Strupińska, A.; Roszak, S.; Prokopowicz, M.; Koole, L. H.; Kafarski P., Theoretical study of spin-spin coupling across the hydrogen (O-H⋯N) bond in adenosine derivatives J. Mol. Model. 2009, 15, 651.
33. Ziora, Z.; Kafarski, P., Amidoalkylation of Phosphorus Trichloride with Acetamide and Alkyl Oxocycloalkanecarboxylates Phosphorus, Sulfur, & Silicon 2009, 184, 1047.
34. Matczak-Jon, E.; Ślepokura, K.; Kafarski, P.; Skrzyńska, I.; Jon, M., Conformational isomers of the [(5-methyl-2-pyridinio)aminomethylene]diphosphonate dianion and [(5-methyl-2-pyridyl)aminomethylene]diphosphonate trianion in salts with 4-aminopyridine and ammonia Acta Cryst. C 2009, 65, 261.
35. Lejczak, B.; Kafarski, P., Biological Activity of Aminophosphonic Acids and Their Short Peptides Top. Heterocycl. Chem. 2009, 20, 31.
36. Dąbrowska, E.; Burzyńska, A.; Mucha, A.; Matczak-Jon, E.; Sawka-Dobrowolska, W.; Berlicki, Ł.; Kafarski, P., Insight into the mechanism of three component condensation leading to aminomethylenebisphosphonates. J. Organomet. Chem. 2009, 694, 3806.
37. Rudzińska, E.; Berlicki, Ł.; Kafarski, P.; Lämmerhofer, M.; Mucha, A., Cinchona alkaloids as privileged chiral solvating agents for enantiodiscrimination of N-protected aminoalkanephosphonates - a comparative NMR study. Tetrahedron Asymmetry 2009, 20, 2709.
38. Prokopowicz, M.; Młynarz, P.; Kafarski, P, Synthesis of phosphonate derivatives of 2,3-dihydroindene Tetrahedron Lett. 2009, 50, 7314.
39. Majewska, P.; Doskocz, M.; Lejczak, B.; Kafarski, P., Enzymatic resolution of α-hydroxyphosphinates with two stereogenic centres and determination of absolute configuration of stereoisomers obtained. Tetrahedron Asymm. 2009, 20, 1568.
40. Dąbrowska, E.; Kafarski, P., Amiomethylenebisphosphonates – a new direction of studies on treatment of osteoporosis OrtopediaTraumatologia i Rehabilitacja 2009, 11, 152.
41. Forlani, G.; Occhipinti, A.; Berlicki, Ł.; Dziędzioła, G.; Wieczorek, A.; Kafarski, P. , Tailoring the Structure of Aminobisphosphonates to Target Plant P5C Reductase. J. Agric. Food Chem. 2008, 56, 3193.
42. Mucha, A.; Laemmerhofer, M.; Lindner, W.; Pawełczak, M.; Kafarski, P., Individual stereoisomers of phosphinic dipeptide inhibitor of leucine aminopeptidase. Bioorg. Med. Chem. Lett. 2008, 18, 1550.
43. Latajka, R.; Krężel, A.; Mucha, A.; Jewgiński, M.; Kafarski, P., Conformational investigations of bis(alpha-aminoalkyl)phosphinic acids and studies of the stability of their complexes with Cu(II). J. Mol. Str. 2008, 877, 64.
44. Minta, E.; Kafarski, P.; Martinez, J.; Rolland, V., Synthesis of cyclooctapeptides: constraints analogues of the peptidic neurotoxin, ω-agatoxine IVB – an experimental point of view J. Pept. Sci. 2008, 14, 267.
45. Żymańczyk-Duda, E.; Brzezińska-Rodak, M.; Klimek-Ochab, M.; Latajka, R.; Kafarski, P. ; Lejczak, B., Chiral O-phosphorylated derivative of 2-hydroxy-2-phenylethylphosphonate as a valuable product of microbial biotransformation of diethyl 2-oxo-2-phenylethylphosphonate J. Mol. Cat. B 2008, 52, 74.
46. Lisowski, M.; Latajka, R.; Picur, B.; Lis, T.; Bryndal, I.; Rospenk, M.; Makowski, M.; Kafarski, P., Combined effect of the dehydro-Phe or dehydro-Ala residue and the p-nitroanilide group on a dehydropeptides conformation Biopolymers 2008, 89, 220.
47. Vassiliou, S.; Grabowiecka, A.; Kosikowska, P.; Yiotakis, A.; Kafarski, P.; Berlicki, Ł., Design, synthesis and evaluation of novel organophosphorus inhibitors of bacterial ureases. J. Med. Chem. 2008, 51, 5736.
48. Cunningham, E.; Drąg, M.; Kafarski, P.; Bell, A., Chemical Target Validation Studies of Aminopeptidase in Malaria Parasites Using alpha-Aminoalkylphosphonate and Phosphonopeptide Inhibitors Antimirob. Agnets Chemother. 2008, 52, 3221.
49. Forlani, G.; Pavan, M.; Gramek, M.; Kafarski, P.; Lipok, J., Biochemical Bases for a Widespread Tolerance of Cyanobacteria to the Phosphonate Herbicide Glyphosate Plant Cell Physiol. 2008, 49, 443.
50. Podstawka, E.; Andrzejak M.; Kafarski, P.; Proniewicz, L. M., Comparison of adsorption mechanism on colloidal silver surface of alafosfalin and its analogs J. Raman Spectrosc. 2008, 39, 1239.
51. Jaskula, B.; Kafarski, P.; Aerts, G.; De Cooman, L., A Kinetic Study on the Isomerization of Hop alpha-Acids J. Agric. Food Chem. 2008, 56, 6408.
52. Młynarz, P.; Olbert-Majkut, A.; Śliwińska, S.; Schroeder, G., Bańkowski, B. Kafarski, P., 1,4-Phenylene-di(N-L-alanylaminomethylphosphonate) a new diaminophosphonate peptide receptor for lysine and arginine J. Mol. Struct. 2008, 873, 173.
53. Młynarz, P.; Czernicka, A.; Rydzewska, A,; Schroeder, G.; Kafarski, P., Tetra-2-methoxyethyl phenylene-1,4-di(benzyloaminomethanephosphonate) a new ligand for metal ions and amino acids. Electrospray ionization mass spectrometric and NMR studies J. Mol. Struct. 2008, 875, 130.
54. Podstawka, E.; Kafarski, P.; Proniewicz, L. M., Effect of an aliphatic spacer group on the adsorption mechanism of phosphonodipeptides containing N-terminal glycine on the colloidal silver surface J. Raman. Spectrosc. 2008, 39, 1396.
55. Latajka, R.; Jewginski, M.; Makowski, M., Pawełczak, M.; Huber, T.; Sewald, N.; Kafarski, P., Pentapeptides containing two dehydrophenylalanine residues - synthesis, structural studies and evaluation of their activity towards cathepsin C J. Pept. Sci. 2008, 14, 1084.
56. Podstawka, E.; Kafarski, P.; Proniewicz, L. M., Structural Properties of L-X-L-Met-L-Ala Phosphonate Tripeptides: A Combined FT-IR, FT-RS, and SERS Spectroscopy Studies and DFT Calculations J. Phys. Chem. A 2008, 112, 11744.
57. Podstawka, E.;Kafarski, P;Proniewicz, L. M., Effect of an aliphatic spacer group on the adsorption mechanism on the colloidal silver surface of L-proline phosphonodipeptides J. Raman Spectrosc. 2008, 39, 1726.
58. Rudzińska, E.; Poliwoda, A.; Berlicki, Ł.; Mucha, A.; Dżygiel, P.; Wiczorek, P.P.; Kafarski, P., Enantiodifferentiation of N-benzyloxycarbonylaminophosphonic and phosphinic acids and their esters using cyclodextrins by means of capillary electrophoresis. J. Chromat. A 2007, 1138, 284.
59. Berlicki, Ł.; Grembecka, J.; Dyguda-Kazimierowicz, E.; Kafarski, P.; Sokalski, W.A., From inhibitors of LAP to inhibitors of PAL. Lessons from Molecular Modeling and Experiment Interface. in Molecular Materials with Specific Interactions (Ed. W. A. Sokalski) 2007, 365.
60. Stack, C. M.; Lowther, J.; Cunningham, E.; Donnelly, S.; Gardiner, D. L.; Trenholme, K. R.; Skinner-Adams, T. S.; Teuscher, F.; Grembecka, J.; Mucha, A.; Kafarski, P.; Lua, L.; Bell, A.; Dalton, J. P., Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development. J. Biol. Chem. 2007, 282, 2069.
61. Forlani, G.; Giberti, S.; Berlicki, Ł.; Petrollino, D.; Kafarski, P., Plant P5C reductase as a new target for aminomethylenebisphosphonates. J. Agric. Food Chem. 2007, 55, 4340.
62. Rudzińska, E.; Berlicki, Ł.; Mucha, A.; Kafarski, P., Analysis of pD Dependent Complexation of N-Benzyloxycarbonylaminophosphonic Acids by a-Cyclodextrin. Enantiodifferentation of Phosphonic Acid pKa V alues Chirality 2007, 19, 764.
63. Młynarz, P.; Rudzińska, E.; Berlicki, Ł.; Kafarski, P., Organophosphorus supramolecular chemistry. Part 2. Organophosphorus receptors Curr. Org. Chem. 2007, 11, 1593.
64. Rudzińska, E.; Berlicki, Ł.; Mucha, A.; Kafarski, P., Chiral discrimination of ethyl and phenyl N-benzyloxycarbonylaminophosphonates by cyclodextrins. Tetrahedron Asymmetry 2007, 18, 1579.
65. Berlicki, Ł.; Mucha, A.; Kafarski, P., A mild and convenient oxidation of H-phosphinic acids. Pol. J. Chem. 2007, 81, 1959.
66. Vassiliou, S.; Xeilari, M.; Yiotakis, A.; Grembecka, J.; Pawelczak, M.; Kafarski, P.; Mucha, A., A synthetic method for diversification of the P1 ' substituent in phosphinic dipeptides as a tool for exploration of the specificity of the S1 ' binding pockets of leucine aminopeptidases. Bioorg. Med. Chem. 2007, 15, 3187.
67. Teuscher, F.; Lowther, J.; Skinner-Adams, T.S.; Spielmann, T.; Dixon, M.W.A.; Stack, C.M.; Donnelly, S.; Mucha, A.; Kafarski, P.; Vassiliou, S.; Gardiner, D.L.; Dalton, J.P.; Trenholme, K.R., The M18 Aspartyl Aminopeptidase of the Human Malaria Parasite Plasmodium falciparum. J. Biol. Chem. 2007, 282, 30817.
68. Skinner-Adams, T. S.; Lowther, J.; Teuscher, F.; Stack, C. M.; Grembecka, J.; Mucha, A.; Kafarski, P.; Trenholme, K. R.; Dalton, J. P.; Gardiner, D. L., Identification of Phosphinate Dipeptide Analog Inhibitors Directed against the Plasmodium falciparum M17 Leucine Aminopeptidase as Lead Antimalarial Compounds. J. Med. Chem. 2007, 50, 6024.
69. Młynarz, P.; Jewginski, M.; Sliwinska, S.; Latajka, R.; Schroeder, G.; Kafarski, P., "Twin" phosphorous atoms of tetraethyl 2-methyl-piperyd-1-ylmethylenebisphosphonates Heteroatom Chem. 2007, 18, 774.
70. Podstawka, E.; Kudelski, A.; Kafarski, P.; Proniewicz L.M., Influence of aliphatic spacer group on adsorption mechanisms of phosphonate derivatives of L-phenylalanine: Surface-enhanced Raman, Raman, and infrared studies Surface Sci. 2007, 601, 4586.
71. Gałęzowska, J.; Szyrwiel, Ł.; Młynarz, P.; Śliwińska, S.; Kafarski, P.; Kozłowski, H., Coordination abilities of difunctional, diaminophosphonic acid and its dipeptides towards Cu(II) ions Polyhedron 2007, 26, 4287.
72. Lipok, J, Owsiak, T,. Młynarz, P. ; Forlani, G. Kafarski P., Phosphorus NMR as a tool to study mineralization of organophosphonates—The ability of Spirulina spp. to degrade glyphosate Enzyme Microb. Technol. 2007, 41, 286.
73. Berlicki, Ł.; Kafarski, P., Computer-aided analysis of the interactions of glutamine synthetase with its inhibitors. Bioorg. Med. Chem. 2006, 14, 4578.
74. Forlani, G.; Obojska, A.; Berlicki, Ł.; Kafarski, P., Phosphinothricin Analogues as Inhibitors of Plant Glutamine Synthetases. J. Agric. Food Chem. 2006, 54, 796.
75. Białas, A.; Grembecka, J.; Krowarsch, D.; Otlewski, J.; Potempa, J.; Mucha, A., Exploring the Sn Binding Pockets in Gingipains by Newly Developed Inhibitors: Structure-Based Design, Chemistry and Activity. J. Med. Chem. 2006, 49, 1744.
76. Matczak-Jon, E.; Slepokura, K.; Kafarski, P., Solid state and solution behaviour of N-(2-pyridyl)- and N-(4-methyl-2-pyridyl)aminomethane-1,1-diphosphonic acids. J. Mol. Struct. 2006, 782, 81.
77. Lyapchenko, N.; Schroeder, G.; Przybylski, P.; Burzynska, A.; Kafarski, P.; Brzezinski, B., Mass spectrometric and PM5 study of some piperidine-N-methyldiphosphonic acids and their complexes with alkali cations. J. Mol. Struct. 2006, 782, 183.
78. Brzezinska-Rodak, M.; Zymanczyk-Duda, E.; Klimek-Ochab, M.; Kafarski, P.; Lejczak, B., A simple and green procedure for the microbial effective synthesis of 1-phenylethyl alcohol in both enantiomeric forms. Biotech. Lett. 2006, 28, 511.
79. Matczak-Jon, E.; Slepokura, K.; Kafarski, P., [(5-Bromopyridinium-2-ylamino)(phosphono)methyl]phosphonate. Acta Crystallogr. C 2006, 62, 132.
80. Berlicki, Ł.; Rudzińska, E.; Młynarz, P.; Kafarski, P., Organophosphorus supramolecular chemistry. Part 1. Receptors for organophosphorus compounds. Curr. Org. Chem. 2006, 10, 2285.
81. Latajka, R.; Makowski, M.; Jewginski, M.; Pawelczak, M.; Koroniak, H.; Kafarski, P., Peptide p-nitrophenylanilides containing (E)-dehydrophenylalanine - synthesis, structural studies and evaluation of their activity towards cathepsin C. New J. Chem. 2006, 30, 1009.
82. Mucha, A.; Kunert, A.; Grembecka, J.; Pawelczak, M.; Kafarski, P., A phosphonamidate containing aromatic N-terminal amino group as inhibitor of leucine aminopeptidase-design, synthesis and stability. Eur. J. Med. Chem. 2006, 41, 768.
83. Matczak-Jon, E.; Kurzak, B.; Kafarski, P.; Wozna, A., Coordination abilities of piperyd-1-yl-methane-1,1-diphosphonic acids towards zinc(II), magnesium(II) and calcium(II): Potentiometric and NMR studies. J. Inorg. Biochem. 2006, 100, 1155.
84. Preinerstorfer, B.; Lubda, D.; Mucha, A.; Kafarski, P.; Lindner, W.; Lämmerhofer, M., Stereoselective separations of chiral phosphinic acid pseudodipeptides by CEC using silica monoliths modified with an anion-exchange-type chiral selector. Electrophoresis 2006, 27, 4312.
85. Jagiełło, M.; Minta, E.; Chojnacka, K.; Kafarski, P., Mode of Biosorption of Chromium(III) by Spirulina Species Cells from Aqueous Solutions Water Environment Research 2006, 78, 740.
86. Majewska, P.; Kafarski, P.; Lejczak, B.; Bryndal, I.; LIs, T., An approach to the synthesis and assignment of the absolute configuration of all enantiomers of ethyl hydroxy(phenyl)methane(P-phenyl)phosphinate Tetrahedron: Asymm. 2006, 17, 2697.
87. Majewska, P.; Kafarski, P.; Lejczak, B., Simple and effective method for the deracemization of ethyl 1-hydroxyphosphinate using biocatalysts with lipolytic activity Tetrahedron: Asymmetry 2006, 17, 2870.